Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis
| Autor: | Chunhua Su, Zhenguang Chen, Weibing Liu, Chiu-Wen Chou, Honghe Luo, Yihua Su, Jianyong Zou |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Respiratory rate Visual analogue scale medicine.medical_treatment Flurbiprofen lcsh:Surgery lcsh:RD78.3-87.3 Postoperative care Heart rate medicine Humans Adverse effect Myasthenia gravis Tramadol Aged Analgesics Pain Postoperative business.industry lcsh:RD1-811 General Medicine Middle Aged Thymectomy Surgery Blood pressure lcsh:Anesthesiology Anesthesia Administration Intravenous Female Cardiology and Cardiovascular Medicine business Research Article medicine.drug |
| Zdroj: | Journal of Cardiothoracic Surgery, Vol 7, Iss 1, p 98 (2012) Journal of Cardiothoracic Surgery |
| ISSN: | 1749-8090 |
| DOI: | 10.1186/1749-8090-7-98 |
| Popis: | Background Post-thymectomy pain in myasthenia gravis (MG) patients can inhibit breathing and coughing. Inappropriate usage of analgesics may exacerbate respiratory inhibition and even cause myasthenic crisis. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to control moderate postoperative pain and is not associated with respiratory inhibition. We hypothesized that flurbiprofen may provide post-thymectomy pain relief without increasing the risk of complications in MG patients. Methods Two hundred MG patients underwent extended thymectomy from March 2006 to December 2010 and were randomly allocated to a flurbiprofen group (110 patients, 50 mg intravenous flurbiprofen axetil) or a control group (90 patients, 100 mg intramuscular tramadol) as postoperative analgesia. Visual analog scale (VAS) pain score, heart rate, blood pressure, respiratory rate, pulse oximetry (SpO2), and adverse effects were recorded before and up to 24 h after drug administration. Results There were no significant differences in the preoperative clinical characteristics of the flurbiprofen and control (tramadol) groups. Both flurbiprofen and tramadol significantly alleviated post-thymectomy pain (p p 2 in either group at all time points. Conclusions Post-thymectomy intravenous administration of flurbiprofen axetil provides safe and effective analgesia for MG patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink