Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes
| Autor: | Harvey J. Kliman, Parker H. Holzer, Lucy Brink, Katherine M. Hofmann, Kristin M. Milano, Hein J. Odendaal, Morgan R. Firestein, William P. Fifer |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Placenta Gestational Age Biology Article Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Image Processing Computer-Assisted medicine Humans reproductive and urinary physiology Inclusion Bodies 030219 obstetrics & reproductive medicine Pregnancy Outcome Calcinosis Obstetrics and Gynecology Trophoblast Human placenta Trophoblasts 030104 developmental biology medicine.anatomical_structure Developmental trajectory Reproductive Medicine embryonic structures Female Biomarkers Developmental Biology |
| Zdroj: | Placenta |
| ISSN: | 0143-4004 |
| Popis: | We sought to examine placentas enriched for trophoblast inclusions (TIs) in order to characterize, quantify, and examine the interrelations between subtypes of TIs to better understand their underlying biology. We examined a cohort of 600 placentas from deliveries between 20(6) and 43(0) weeks of gestation. Forty-five percent of the placentas had at least one TI in the two slides examined. Four percent of the placentas had 10 or more TIs and two placentas had more than 70 TIs. Four distinct TI types were observed: inclusionoids (early forming inclusions), inclusions, calcified inclusions, and calcified bodies. We suggest this reflects a developmental trajectory of TI maturation, the timing of which might be useful when comparing TI expression to clinical outcomes. |
| Databáze: | OpenAIRE |
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