Case study of patents related to captopril, Squibb’s first blockbuster
| Autor: | Iolanda M. Fierro, Jorge de Paula Costa Ávila, Rafaela Di Sabato Guerrante, Flavia Maria Lins Mendes, Adelaide Maria de Souza Antunes |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Captopril Drug Industry Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology Pharmacology Patents as Topic 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Humans Intensive care medicine Drug industry Antihypertensive Agents business.industry General Medicine 030104 developmental biology Cardiovascular Diseases Drug Design Hypertension business medicine.drug |
| Zdroj: | Expert Opinion on Therapeutic Patents. 26:1449-1457 |
| ISSN: | 1744-7674 1354-3776 |
| DOI: | 10.1080/13543776.2016.1227321 |
| Popis: | Arterial hypertension affects over one billion people around the world, making the prevention and treatment of this disease vital. Despite the efforts made to develop new antihypertensive drugs, few new therapies have become available. Angiotensin-converting enzyme (ACE) inhibitors have heralded major steps forward in the treatment of arterial hypertension and cardiovascular diseases since the first compound of this class, captopril, was approved for clinical use in 1981. Areas covered: In this review, the authors investigated the patent documents that cite the priority patent for captopril, Squibb's first blockbuster, or any other patent from its patent family. The documents were classified into the following: new compounds, new compositions, treatment, process (preparation of a compound), use of a compound, and process for the preparation of an intermediate. Therefore, the readers can identify potential innovations in the field. Expert opinion: The pharmaceutical sector has attempted to provide significant technological developments on anti-hypertensive drugs based on the patenting of captopril, including the development of new compositions further comprising an ACE inhibitor and other antihypertensive agent, along with dual action compounds, novel molecules with dual activity. The target is to find a new agent with better blood pressure-lowering efficacy, improved safety and good tolerability profile. |
| Databáze: | OpenAIRE |
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