Angiogenic growth factors in rheumatoid arthritis
Autor: | Ina Fuhrhop, Bernd Fink, Malte Schroeder, Lennart Viezens, Wolfgang Rüther, Britta Schwarzloh, Christian Schaefer, Nils Hansen-Algenstaedt, Petra Algenstaedt |
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Rok vydání: | 2011 |
Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis Immunology Osteoarthritis Arthritis Rheumatoid Angiopoietin Pathogenesis chemistry.chemical_compound Rheumatology Internal medicine medicine Humans Immunology and Allergy Angiogenic Proteins Aged biology business.industry Synovial Membrane Middle Aged medicine.disease Receptor TIE-2 Angiopoietin receptor Vascular endothelial growth factor Receptors Vascular Endothelial Growth Factor Endocrinology chemistry Rheumatoid arthritis cardiovascular system biology.protein Female business Angiopoietins |
Zdroj: | Rheumatology International. 33:523-527 |
ISSN: | 1437-160X 0172-8172 |
DOI: | 10.1007/s00296-011-2210-6 |
Popis: | We investigated whether the angiogenic profile, which is based on the local expression and systemic levels of angiogenic growth factors (VEGF, Ang-1, Ang-2, and the corresponding receptors), differs between rheumatoid arthritis (RA) and osteoarthritis (OA) patients. We determined the expression of VEGF, Ang-1, and Ang-2 together with its receptors (VEGFR-1/-2 and Tie2) in synovium tissue (ST) and muscular tissue (MT) from patients with RA and OA using quantitative PCR. Tissue samples were obtained from 15 RA and 19 OA patients during total knee arthroplasty. Control MT samples (n = 10) were obtained during spinal surgery. Results are correlated to VEGF and angiopoietin serum levels via ELISA measurements. The VEGF expressions in ST and serum levels were significantly higher in RA patients than in OA patients (P < 0.05). Furthermore, the VEGFR-1 and VEGFR-2 expression in ST from RA patients were significantly higher than in OA patients (P < 0.001 and P < 0.05). The relative concentration of angiopoietins (Ang-1/Ang-2 ratio) was significantly increased in RA (P < 0.01). Serum levels for Ang-2 showed no significant differences. Statistical analysis showed a significant higher level of Tie2 in RA patients (P < 0.001). Analysis of local levels of VEGF, VEGFR-1, VEGFR-2, Ang-1, Ang-2, and Tie2 in the muscular tissue showed no significant difference between RA and OA patients. These results underline the importance of pro-angiogenic growth factor levels for RA corroborating the assumption that VEGF and angiopoietins play an important role in the pathogenesis of RA. |
Databáze: | OpenAIRE |
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