Benzimidazole-derived Compounds Designed for Different Targets of Alzheimer's Disease
| Autor: | Ilkay Erdogan Orhan, Hayrettin Ozan Gulcan, Açelya Mavideniz, Mustafa Fethi Sahin |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Benzimidazole media_common.quotation_subject Histamine Antagonists Peroxisome proliferator-activated receptor 01 natural sciences Biochemistry 03 medical and health sciences chemistry.chemical_compound Alzheimer Disease Drug Discovery Moiety Humans Gamma secretase 030304 developmental biology media_common Pharmacology chemistry.chemical_classification 0303 health sciences Organic Chemistry Glutaminyl cyclase Aminoacyltransferases Cholinesterase inhibition 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine Benzimidazoles Cholinesterase Inhibitors Amyloid Precursor Protein Secretases Benzimidazole derivative Histamine |
| Zdroj: | Current medicinal chemistry. 26(18) |
| ISSN: | 1875-533X |
| Popis: | Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various benzimidazole drugs, available today, employed for the treatment of different diseases. Although there is no benzimidazole moiety containing a drug used in clinic today for the treatment of Alzheimer’s Disease (AD), there have been many benzimidazole derivative compounds designed and synthesized to act on some of the validated and non-validated targets of AD. This paper aims to review the literature to describe these benzimidazole containing molecules designed to target some of the biochemical cascades shown to be involved in the development of AD. |
| Databáze: | OpenAIRE |
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