Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia
| Autor: | N. Anim-Nyame, Mark R. Johnson, Philip J. Steer, Suren R. Sooranna |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Leptin medicine.medical_specialty Blood Pressure Gestational Age Body Mass Index Preeclampsia Pre-Eclampsia Pregnancy Internal medicine Blood plasma Humans Medicine Longitudinal Studies reproductive and urinary physiology Eclampsia Platelet Count business.industry Rehabilitation Obstetrics and Gynecology Gestational age medicine.disease female genital diseases and pregnancy complications Uric Acid Cross-Sectional Studies Endocrinology Blood pressure Reproductive Medicine Gestation Female business |
| Zdroj: | Human Reproduction. 15:2033-2036 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/15.9.2033 |
| Popis: | Leptin concentrations have been found to be elevated in cross-sectional studies of established pre-eclampsia. Circulating concentrations of leptin were measured in a cross-sectional study to confirm these findings (19 women with pre-eclampsia and 13 normal pregnant controls) and in a longitudinal study to establish the timing of the increase in leptin concentrations (samples obtained at 16, 20, 24, 28, 32, 36 and 38 weeks gestation from eight women who went on to develop pre-eclampsia and seven normal pregnant controls). In the cross-sectional study, plasma leptin concentrations were significantly greater in women with pre-eclampsia than in normal controls (P: = 0.001). In the longitudinal study, it was found that circulating leptin concentrations rose gradually to 32 weeks and thereafter declined slightly in normals. The concentrations in women destined to develop pre-eclampsia were consistently higher from 20 weeks gestation (P: = 0.04-0.003) and, in contrast to the normal controls, rose markedly from 32 weeks as pre-eclampsia developed. This study confirms that plasma leptin concentrations are increased in established pre-eclampsia and reports for the first time that leptin concentrations are elevated before pre-eclampsia is clinically evident. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|