Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study

Autor:	Atsushi Kato, Hiroki Yamaguchi, Koiti Inokuchi, Kazuma Ohyashiki, Satoshi Takahashi, Hirokazu Okumura, Arinobu Tojo, Seiji Gomi, Kazuo Dan, Naoto Takahashi, Fumiharu Yagasaki, Hisashi Sakamaki, Kazuo Oshimi, Ayako Arai, Noriko Usui, Masami Bessho, Shinji Nakao, Hiroyuki Hamaguchi, Kenichi Sawada, Ken Ohmine, Keisuke Miyazawa, Keiya Ozawa, Takeshi Kobayashi, Yoshiro Murai, Hayato Tamai, Osamu Miura, Shigeo Toyota, Hideki Akiyama
Rok vydání:	2008
Předmět:	Adult Male medicine.medical_specialty Myeloid medicine.medical_treatment Hematopoietic stem cell transplantation Gastroenterology Disease-Free Survival Translocation Genetic Cohort Studies hemic and lymphatic diseases Internal medicine medicine Humans Transplantation Homologous Retrospective Studies Acute leukemia Hematology business.industry Chromosomes Human Pair 11 Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Myeloid leukemia Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Surgery Transplantation Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Female business
Zdroj:	International Journal of Hematology. 87:195-202
ISSN:	1865-3774 0925-5710
DOI:	10.1007/s12185-008-0034-2
Popis:	To clarify the clinical features of adult patients with acute leukemia (AL) with 11q23 abnormalities, we performed a retrospective analysis of data from 58 adult Japanese patients: 51 with acute myeloid leukemia (AML), and 7 with acute lymphoblastic leukemia (ALL). The incidences according to fusion partners in AML were: t(9;11), 31.3%; t(11;19), 27.4%; t(6;11), 21.5%. The incidence of patients with t(11;19) was higher than those in the US and Europe, and the incidence of t(4;11) was lower than that in childhood. The results indicated the poor prognosis of AML with 11q23 abnormalities regardless of the fusion partners. AML patients with 11q23 aged
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a4af55a9a5150eb6f610d4cc438258 https://doi.org/10.1007/s12185-008-0034-2 Zobrazit plný text záznamu Full text from SpringerLink