Natural products in drug discovery: advances and opportunities

Autor: Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T.
Přispěvatelé: Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T.
Rok vydání: 2021
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature reviews. Drug discovery
(2021). doi:10.1038/s41573-020-00114-z
info:cnr-pdr/source/autori:Atanasov A.G.; Zotchev S.B.; Dirsch V.M.; Orhan I.E.; Banach M.; Rollinger J.M.; Barreca D.; Weckwerth W.; Bauer R.; Bayer E.A.; Majeed M.; Bishayee A.; Bochkov V.; Bonn G.K.; Braidy N.; Bucar F.; Cifuentes A.; D'Onofrio G.; Bodkin M.; Diederich M.; Dinkova-Kostova A.T.; Efferth T.; El Bairi K.; Arkells N.; Fan T.-P.; Fiebich B.L.; Freissmuth M.; Georgiev M.I.; Gibbons S.; Godfrey K.M.; Gruber C.W.; Heer J.; Huber L.A.; Ibanez E.; Kijjoa A.; Kiss A.K.; Lu A.; Macias F.A.; Miller M.J.S.; Mocan A.; Muller R.; Nicoletti F.; Perry G.; Pittala V.; Rastrelli L.; Ristow M.; Russo G.L.; Silva A.S.; Schuster D.; Sheridan H.; Skalicka-Wozniak K.; Skaltsounis L.; Sobarzo-Sanchez E.; Bredt D.S.; Stuppner H.; Sureda A.; Tzvetkov N.T.; Vacca R.A.; Aggarwal B.B.; Battino M.; Giampieri F.; Wink M.; Wolfender J.-L.; Xiao J.; Yeung A.W.K.; Lizard G.; Popp M.A.; Heinrich M.; Berindan-Neagoe I.; Stadler M.; Daglia M.; Verpoorte R.; Supuran C.T./titolo:Natural products in drug discovery: advances and opportunities/doi:10.1038%2Fs41573-020-00114-z/rivista:Nature reviews. Drug discovery (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Nature Reviews. Drug Discovery
Nature Reviews in Drug Discovery
ISSN: 1474-1784
1474-1776
Popis: The International Natural Product Sciences Taskforce: et al.
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
A.C. and E.I. thank the Ministerio de Ciencia, Innovación y Universidades, Spain (Project AGL2017-89417-R) for support. F.A.M. acknowledges the support by Ministerio de Economia y Competitividad, Spain (project AGL2017-88083-R).
Databáze: OpenAIRE
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