Natural products in drug discovery: advances and opportunities
Autor: | Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T. |
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Přispěvatelé: | Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T. |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Engineering Drug Industry Review Article Communicable Diseases Natural (archaeology) 03 medical and health sciences 0302 clinical medicine Transferases Neoplasms Drug Discovery Humans Pharmaceutical industry Pharmacology Biological Products Natural products Genome business.industry Drug discovery General Medicine Chemical biology 030104 developmental biology Risk analysis (engineering) 030220 oncology & carcinogenesis Genome mining business |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Nature reviews. Drug discovery (2021). doi:10.1038/s41573-020-00114-z info:cnr-pdr/source/autori:Atanasov A.G.; Zotchev S.B.; Dirsch V.M.; Orhan I.E.; Banach M.; Rollinger J.M.; Barreca D.; Weckwerth W.; Bauer R.; Bayer E.A.; Majeed M.; Bishayee A.; Bochkov V.; Bonn G.K.; Braidy N.; Bucar F.; Cifuentes A.; D'Onofrio G.; Bodkin M.; Diederich M.; Dinkova-Kostova A.T.; Efferth T.; El Bairi K.; Arkells N.; Fan T.-P.; Fiebich B.L.; Freissmuth M.; Georgiev M.I.; Gibbons S.; Godfrey K.M.; Gruber C.W.; Heer J.; Huber L.A.; Ibanez E.; Kijjoa A.; Kiss A.K.; Lu A.; Macias F.A.; Miller M.J.S.; Mocan A.; Muller R.; Nicoletti F.; Perry G.; Pittala V.; Rastrelli L.; Ristow M.; Russo G.L.; Silva A.S.; Schuster D.; Sheridan H.; Skalicka-Wozniak K.; Skaltsounis L.; Sobarzo-Sanchez E.; Bredt D.S.; Stuppner H.; Sureda A.; Tzvetkov N.T.; Vacca R.A.; Aggarwal B.B.; Battino M.; Giampieri F.; Wink M.; Wolfender J.-L.; Xiao J.; Yeung A.W.K.; Lizard G.; Popp M.A.; Heinrich M.; Berindan-Neagoe I.; Stadler M.; Daglia M.; Verpoorte R.; Supuran C.T./titolo:Natural products in drug discovery: advances and opportunities/doi:10.1038%2Fs41573-020-00114-z/rivista:Nature reviews. Drug discovery (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume Nature Reviews. Drug Discovery Nature Reviews in Drug Discovery |
ISSN: | 1474-1784 1474-1776 |
Popis: | The International Natural Product Sciences Taskforce: et al. Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities. A.C. and E.I. thank the Ministerio de Ciencia, Innovación y Universidades, Spain (Project AGL2017-89417-R) for support. F.A.M. acknowledges the support by Ministerio de Economia y Competitividad, Spain (project AGL2017-88083-R). |
Databáze: | OpenAIRE |
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