Analysis of KIR gene frequencies and HLA class I genotypes in breast cancer and control group
| Autor: | Jorge Villanova Biazús, Rafael Roesler, Ana Cristina da Costa Bittelbrunn, Mariana Jobim, Pâmela Portela, Sandra Leistner-Segal, Carlos Henrique Menke, Patrícia Hartstein Salim, Luiz Fernando Job Jobim, Gilberto Schwartsmann, Maria Regina Sampaio Leite Jobim |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Genotype Immunology Cell Genes MHC Class I Breast Neoplasms chemical and pharmacologic phenomena HLA-C Antigens Human leukocyte antigen Biology White People Breast cancer Gene Frequency Receptors KIR Cell surface receptor medicine Humans Immunology and Allergy Allele Receptor Genetic Association Studies Innate immune system Histocompatibility Testing General Medicine Middle Aged medicine.disease Killer Cells Natural medicine.anatomical_structure HLA-B Antigens Receptors KIR2DL2 Female Brazil |
| Zdroj: | Human Immunology. 74:1130-1133 |
| ISSN: | 0198-8859 |
| Popis: | Breast cancer is the main cause of cancer-related death among women, with a 0.5% increase in incidence per year. Natural killer cells (NK) are part of the innate immune system recognizing class I HLA molecules on target cells through their membrane receptors, called killer cell immunoglobulin-like receptors (KIR). The aim of our study was to evaluate the association between the KIR genes and HLA alleles in patients with breast cancer and healthy controls. Two hundred thirty patients with breast cancer and 272 healthy controls were typed for HLA class I and KIR genes by PCR-SSO. When both groups were compared, the presence of inhibitory KIR2DL2 receptors was significantly higher in breast cancer patients than in healthy controls. No significant differences were found for HLA-C2 and HLA-Bw4. However, a higher frequency of HLA-C1 in breast cancer patients was observed. These findings suggest a potential role for the KIR gene system in breast cancer. Further studies to confirm this observation are warranted. |
| Databáze: | OpenAIRE |
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