Long-Term Antibody and Immune Memory Response Induced by Pulmonary Delivery of the Influenza Iscomatrix Vaccine
| Autor: | Janet L. Wee, Stirling John Edwards, Martin J. Pearse, Kenneth J. Snibson, Jean-Pierre Y. Scheerlinck, Philip Sutton, Ana Vujanic |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Time Factors Influenza vaccine medicine.medical_treatment Clinical Biochemistry Immunology Antibodies Viral Immune system Adjuvants Immunologic Antigen Administration Inhalation medicine Animals Immunology and Allergy Lung Phospholipids Vaccines Sheep Hemagglutination assay biology business.industry Vaccination Hemagglutination Inhibition Tests Saponins Virology Drug Combinations Blood Cholesterol Immunization Influenza Vaccines biology.protein Female Antibody business Immunologic Memory Adjuvant |
| Zdroj: | Clinical and Vaccine Immunology. 19:79-83 |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | Pulmonary delivery of an influenza Iscomatrix adjuvant vaccine induces a strong systemic and mucosal antibody response. Since an influenza vaccine needs to induce immunological memory that lasts at least 1 year for utility in humans, we examined the longevity of the immune response induced by such a pulmonary vaccination, with and without antigen challenge. Sheep were vaccinated in the deep lung with an influenza Iscomatrix vaccine, and serum and lung antibody levels were quantified for up to 1 year. The immune memory response to these vaccinations was determined following antigen challenge via lung delivery of influenza antigen at 6 months and 1 year postvaccination. Pulmonary vaccination of sheep with the influenza Iscomatrix vaccine induced antigen-specific antibodies in both sera and lungs that were detectable until 6 months postimmunization. Importantly, a memory recall response following antigenic challenge was detected at 12 months post-lung vaccination, including the induction of functional antibodies with hemagglutination inhibition activity. Pulmonary delivery of an influenza Iscomatrix vaccine induces a long-lived influenza virus-specific antibody and memory response of suitable length for annual vaccination against influenza. |
| Databáze: | OpenAIRE |
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