| Autor: |
Satoshi Asaka, Chritoph Winkler, Hiroshi Suwa, Chikako Morinaga, Sylke Winkler, Masakazu Osakada, Takao Sasado, Kota Saito, Thorsten Henrich, Akihito Yasuoka, Sanae Kunimatsu, Felix Loosli, Hiroshi Nishina, Rebecca Quiring, Katsutoshi Niwa, Akihiro Momoi, Harun Elmasri, Hiroki Yoda, Yukihiro Hirose, Toshiaki Katada, Norimasa Iwanami, Tomonori Deguchi, Tomomi Watanabe, Matthias Carl, Makoto Furutani-Seiki, Filippo Del Bene, Daiju Kitagawa, Clemens Grabher, Joachim Wittbrodt, Hisato Kondoh |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Mechanisms of Development. 121(7-8):673-685 |
| ISSN: |
0925-4773 |
| DOI: |
10.1016/j.mod.2004.03.010 |
| Popis: |
The forebrain, consisting of the telencephalon and diencephalon, is essential for processing sensory information. To genetically dissect formation of the forebrain in vertebrates, we carried out a systematic screen for mutations affecting morphogenesis of the forebrain in Medaka. Thirty-three mutations defining 25 genes affecting the morphological development of the forebrain were grouped into two classes. Class 1 mutants commonly showing a decrease in forebrain size, were further divided into subclasses 1A to 1D. Class 1A mutation (1 gene) caused an early defect evidenced by the lack of bf1 expression, Class 1B mutations (6 genes) patterning defects revealed by the aberrant expression of regional marker genes, Class 1C mutation (1 gene) a defect in a later stage, and Class 1D (3 genes) a midline defect analogous to the zebrafish one-eyed pinhead mutation. Class 2 mutations caused morphological abnormalities in the forebrain without considerably affecting its size, Class 2A mutations (6 genes) caused abnormalities in the development of the ventricle, Class 2B mutations (2 genes) severely affected the anterior commissure, and Class 2C (6 genes) mutations resulted in a unique forebrain morphology. Many of these mutants showed the compromised sonic hedgehog expression in the zona-limitans-intrathalamica (zli), arguing for the importance of this structure as a secondary signaling center. These mutants should provide important clues to the elucidation of the molecular mechanisms underlying forebrain development, and shed new light on phylogenically conserved and divergent functions in the developmental process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect