CD68 and factor XIIIa expressions in granular-cell tumor of the skin
| Autor: | Gérald Pierard, J. Arrese Estrada, Arjen Nikkels, Claudine Piérard-Franchimont |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cytoplasm Skin Neoplasms Schwann cell Antigens Differentiation Myelomonocytic Gene Expression Vimentin Dermatology Schwannoma Cytoplasmic Granules law.invention law Antigens CD medicine Humans Granular cell tumor Transglutaminases biology CD68 S100 Proteins Fibroblasts medicine.disease medicine.anatomical_structure Granular Cell Tumor biology.protein Immunohistochemistry Female Factor XIIIa Electron microscope |
| Zdroj: | Dermatology (Basel, Switzerland). 186(2) |
| ISSN: | 1018-8665 |
| Popis: | Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using antibodies to CD68, S-100 proteins, factor XIIIa, L1 antigen, desmin and vimentin. The CD68 monocyte-macrophage-associated lysosomal antigen was expressed in granular cells which however had no Mac 387 reactivity. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. |
| Databáze: | OpenAIRE |
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