Additional diagnostic accuracy of global longitudinal strain at peak dobutamine stress in patients with moderate pretest probability of coronary artery disease
| Autor: | Dalia R. Elremisy, Mohamed Hassan, Waleed Ammar, Hesham S. Taha, Ahmed Elamragy, Mohamed Abdelwahab |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Longitudinal strain Diagnostic accuracy Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Sensitivity and Specificity Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine Dobutamine medicine Cutoff Humans Radiology Nuclear Medicine and imaging In patient 030212 general & internal medicine Myocardial infarction Probability business.industry Area under the curve Middle Aged medicine.disease Pre- and post-test probability Cardiology Female Cardiology and Cardiovascular Medicine business Echocardiography Stress |
| Zdroj: | Echocardiography (Mount Kisco, N.Y.)REFERENCES. 37(8) |
| ISSN: | 1540-8175 |
| Popis: | BACKGROUND Previous studies confirmed the feasibility of 2D speckle tracking echocardiography (2D STE) during dobutamine stress echocardiography (DSE) in assessing myocardial ischemia in patients with previous myocardial infarction. It is unknown whether it improves the diagnostic accuracy in young patients with intermediate pretest probability for coronary artery disease (CAD) and no prior cardiovascular events. METHODS We prospectively studied 101 patients by DSE and STE, followed by coronary angiography within 1 month. Significant CAD was defined as diameter stenosis ≥ 50%. Receiver operating characteristic analysis obtained global longitudinal strain (GLS) cutoff values of significant area under the curve (AUC). RESULTS Mean age: 53 ± 8 years, 56% females, 49 had significant CAD (group 1) and 52 had normal/mild CAD (group 2); no significant baseline differences except more males in group 1 (P: .002). DSE sensitivity and specificity for CAD were 79.6% and 92.3%, respectively, positive predictive value (PPV): 90.6%, negative predictive value (NPV): 82.7%, and diagnostic accuracy: 86%. At peak stress, all strain parameters were significantly lower in group 1. However, GLS had the highest AUC: 0.88, P |
| Databáze: | OpenAIRE |
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