Effect of Intraperitoneal Administered Ginseng Total Saponins on Hyperalgesia Induced by Repeated Intramuscular Injection of Acidic Saline in Rats
| Autor: | Hwa Yong Shin, Jungeun Kim, Su Hyun Kim, Chong Wha Baek, Hyun Kang, Won Joong Kim, Geun Joo Choi, Jeong Hyuk Lee, Young Choel Woo, Yong Hun Jung |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pain Threshold N-Methylaspartate medicine.medical_treatment Intraperitoneal injection Panax Medicine (miscellaneous) (+)-Naloxone Sodium Chloride Pharmacology Injections Intramuscular Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley Ginseng medicine Animals Muscle Skeletal Saline Analgesics Nutrition and Dietetics Plant Extracts business.industry Saponins Nociception Hyperalgesia NMDA receptor medicine.symptom Full Communications Intramuscular injection business human activities Phytotherapy |
| Zdroj: | Journal of Medicinal Food. 17:657-662 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | The aim of this study was to assess the antinociceptive activity of ginseng total saponins (GTS) on hyperalgesia induced by repeated intramuscular injections of acidic saline in rats and to examine the mechanisms involved. Rats were injected intraperitoneally with a 0.9% saline vehicle or various doses of GTS after the development of hyperalgesia. Rats were then injected with N-methyl-D-aspartate (NMDA) or naloxone 10 min before GTS injection. The mechanical withdrawal threshold (MWT) was assessed with von Frey filaments. The MWT was significantly increased after intraperitoneal injection of 100 mg/kg and 200 mg/kg of GTS when compared with the MWT after the development of hyperalgesia. Injection of GTS with NMDA showed a significant decrease in the MWT when compared with GTS injection. GTS showed an antinociceptive activity against chronic muscle-induced pain, and the effect of GTS may be mediated by NMDA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|