Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes
| Autor: | Maria Stella Gonçalves Raddi, Luiz Marcos da Fonseca, Rodrigo Rezende Kitagawa, Wagner Vilegas, Cibele Bonacorsi |
|---|---|
| Přispěvatelé: | Universidade Federal do Espírito Santo (UFES), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
medicine.medical_treatment lcsh:RS1-441 Chronic gastritis Pharmacology lcsh:Pharmacy and materia medica Immune system medicine Helicobacter oxidative burst General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Reactive oxygen species Helicobacter pylori Paepalanthus latipes biology biology.organism_classification medicine.disease Respiratory burst chemistry Immunology 5-methoxy-3 4-dehydroxanthomegnin Gastritis medicine.symptom |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 53-59 (2012) SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Revista Brasileira de Farmacognosia, Volume: 22, Issue: 1, Pages: 53-59, Published: 21 OCT 2011 Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 53-59 (2011) Revista Brasileira de Farmacognosia v.22 n.1 2012 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| ISSN: | 0102-695X |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:50Z No. of bitstreams: 1 S0102-695X2012000100008.pdf: 736403 bytes, checksum: b032e0d8d2e6642c62c606f9d26f8020 (MD5) Made available in DSpace on 2013-08-22T18:57:50Z (GMT). No. of bitstreams: 1 S0102-695X2012000100008.pdf: 736403 bytes, checksum: b032e0d8d2e6642c62c606f9d26f8020 (MD5) Previous issue date: 2012-02-01 Made available in DSpace on 2013-09-30T19:52:56Z (GMT). No. of bitstreams: 2 S0102-695X2012000100008.pdf: 736403 bytes, checksum: b032e0d8d2e6642c62c606f9d26f8020 (MD5) S0102-695X2012000100008.pdf.txt: 32890 bytes, checksum: dbd64f748ed1647c0e6404fbe49b2a62 (MD5) Previous issue date: 2012-02-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:12:18Z No. of bitstreams: 2 S0102-695X2012000100008.pdf: 736403 bytes, checksum: b032e0d8d2e6642c62c606f9d26f8020 (MD5) S0102-695X2012000100008.pdf.txt: 32890 bytes, checksum: dbd64f748ed1647c0e6404fbe49b2a62 (MD5) Made available in DSpace on 2014-05-20T13:12:18Z (GMT). No. of bitstreams: 2 S0102-695X2012000100008.pdf: 736403 bytes, checksum: b032e0d8d2e6642c62c606f9d26f8020 (MD5) S0102-695X2012000100008.pdf.txt: 32890 bytes, checksum: dbd64f748ed1647c0e6404fbe49b2a62 (MD5) Previous issue date: 2012-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated with an increased Helicobacter pyloririsk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and oxidative burst antioxidantactivitiesofa1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. Paepalanthus latipes The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol- and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections. Universidade Federal do Espírito Santo (UFES) Departamento de Ciências Farmacêuticas Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista Instituto de Química de Araraquara Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Universidade Estadual Paulista Instituto de Química de Araraquara |
| Databáze: | OpenAIRE |
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