Somatostatin Receptor-negative and Fluorodeoxyglucose-positron Emission Tomography-positive Lung Neuroendocrine Tumor G1 Exhibiting Cyclic Cushing's Syndrome

Autor:	Chiaki, Nomura, Yujiro, Nakano, Takeo, Tanaka, Kosuke Robert, Shima, Mitsuhiro, Kometani, Takehiro, Kanamori, Hiroko, Ikeda, Yumie, Takeshita, Takashi, Yoneda, Toshinari, Takamura
Rok vydání:	2022
Předmět:	Lung Neoplasms Carcinoid Tumor General Medicine Carcinoma Neuroendocrine ACTH Syndrome Ectopic Neuroendocrine Tumors Fluorodeoxyglucose F18 Positron-Emission Tomography Internal Medicine Humans Female Receptors Somatostatin Somatostatin Cushing Syndrome Lung Aged
Zdroj:	Internal Medicine. 61:3693-3698
ISSN:	1349-7235 0918-2918
DOI:	10.2169/internalmedicine.9238-21
Popis:	Localization of ectopic cyclic Cushing's syndrome, which causes life-threatening complications, is challenging. A 70-year-old woman showed cyclic hypokalemia and hyperglycemia and was diagnosed with cyclic ectopic Cushing's syndrome. Although somatostatin-receptor scintigraphy failed to localize the responsible tumor, fluorodeoxyglucose-positron emission tomography (FDG-PET) showed the uptake of tracer in a lung tumor. Lobectomy resulted in remission. The resected adrenocorticotropic hormone (ACTH)-producing neuroendocrine tumor had Ki-672% and negative staining for somatostatin receptors. This is the first case assessed both radiological findings and pathological findings in cyclic ectopic Cushing's syndrome. Subsequent FDG-PET is recommended if somatostatin-receptor scintigraphy is negative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39dc11771130619595c3e10ac88a3e5 https://doi.org/10.2169/internalmedicine.9238-21 Zobrazit plný text záznamu