Suitability of Calcium Phosphate Cement for Injection Laryngoplasty in Rabbits
| Autor: | Takekatsu Fujimine, Akihiro Shiotani, Kaoru Ogawa, Kaori Kameyama, Takuji Takaoka, Asako Ikeda, Masayuki Tomifuji, Yuko Mori |
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| Rok vydání: | 2006 |
| Předmět: |
Calcium Phosphates
medicine.medical_specialty chemistry.chemical_element Biocompatible Materials Vocal Cords macromolecular substances Calcium Living body medicine Animals Calcium phosphate cement Cement Chemistry technology industry and agriculture Biocompatible material Injection laryngoplasty Otorhinolaryngologic Surgical Procedures Surgery Autologous fat Otorhinolaryngology Microscopy Electron Scanning Rabbits Larynx Crystallization Calcium hydroxylapatite Vocal Cord Paralysis Biomedical engineering |
| Zdroj: | ORL. 68:103-109 |
| ISSN: | 1423-0275 0301-1569 |
| DOI: | 10.1159/000091212 |
| Popis: | Calcium phosphate cement (CPC) consists of powder and liquid, which become an injectable paste after mixing, self-hardening and recrystallizing to calcium hydroxylapatite (CaHA) after injection into a living body. In this study, we investigated the suitability of CPC as an injectable material for injection laryngoplasty using rabbits. All rabbits underwent left recurrent laryngeal nerve section and injection laryngoplasty with CPC. At 7 days, scanning electron microscopic findings revealed that complete recrystallization from CPC to CaHA was achieved in the larynx. At 1, 3, and 6 months, injected CPC stayed in the paraglottic space and did not migrate, and the average remaining CPC volume percentage was 91.7%. Focal foreign body reaction to injected CPC was almost the same as that of autologous fat for all time periods observed. These results indicated that CPC appears to be biocompatible, nonabsorbable, nonmigratory, and suitable for injection laryngoplasty. |
| Databáze: | OpenAIRE |
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