Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: Comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis
Autor: | Guangwen Zhang, Xichun Peng, Liu Liu, Junsheng Liu |
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Rok vydání: | 2021 |
Předmět: |
Male
education Prostatitis Pharmacology Gut flora Coriobacteriaceae digestive system Biochemistry Rats Sprague-Dawley chemistry.chemical_compound Polysaccharides Structural Biology Prostate Animals Medicine Molecular Biology Phylogeny health care economics and organizations Testosterone biology business.industry Finasteride Organ Size General Medicine biology.organism_classification medicine.disease Gastrointestinal Microbiome medicine.anatomical_structure chemistry Dihydrotestosterone Chronic Disease Androgens Cytokines Inflammation Mediators business Biomarkers Wolfiporia medicine.drug Ruminococcaceae |
Zdroj: | International Journal of Biological Macromolecules. 189:346-355 |
ISSN: | 0141-8130 |
Popis: | Finasteride is an antiandrogenic drug used for the clinical treatment of chronic nonbacterial prostatitis (CNP). Recently, we reported the anti-CNP activity of Poria cocos polysaccharides (PPs) in a rat model. In this study, we compared the differences between PPs and finasteride in treating CNP, especially their effects on the gut microbiota. Results showed that both PPs and finasteride significantly reduced the prostate weight and prostate index of CNP rats, and improved the histological damages in the inflamed prostate. Moreover, PPs and finasteride inhibited the production of pro-inflammatory cytokines (TNF-α, IL-2 and IL-8) and androgens (dihydrotestosterone and testosterone). By 16S rDNA sequencing, PPs and finasteride were found to reprogram the gut microbiota into distinct profiles. Further analysis presented that PPs but not finasteride recovered CNP-induced changes in the gut microbiota, including Ruminococcaceae NK4A214 group, uncultured bacterium f Ruminococcaceae, Ruminiclostridium 9, Phascolarctobacterium, Coriobacteriaceae UCG-002 and Oribacterium. LDA effect size (LEfSe) analysis revealed that PPs recovered the gut microbiota by targeting Ruminococcaceae NK4A214 group. Our results suggested that PPs alleviated CNP via different mechanisms from finasteride, especially by regulating the gut microbiota, which offers therapeutic target for the treatment of CNP. |
Databáze: | OpenAIRE |
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