New paradigms of CFTR chloride channel regulation
| Autor: | K. L. Kirk |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Diarrhea
congenital hereditary and neonatal diseases and abnormalities Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator ATP-binding cassette transporter Gating Cystic fibrosis Cellular and Molecular Neuroscience medicine Animals Humans Molecular Biology Ion channel Pharmacology Water transport Membrane Traffic biology Chemistry Cell Biology respiratory system medicine.disease digestive system diseases Cystic fibrosis transmembrane conductance regulator respiratory tract diseases Cell biology Biochemistry Chloride channel biology.protein Molecular Medicine |
| Zdroj: | Cellular and Molecular Life Sciences. 57:623-634 |
| ISSN: | 1420-682X |
| DOI: | 10.1007/pl00000724 |
| Popis: | The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel controls salt and water transport across epithelial tissues. Alterations in the activity of this ion channel lead to two major human diseases: cystic fibrosis (low CFTR activity) and secretory diarrhea (excessive CFTR activity). The goal of this article is to review recent developments in our understanding of two aspects of CFTR biology: (i) interactions between CFTR domains (intramolecular interactions) that control the gating of this epithelial chloride channel and (ii) interactions between CFTR and other proteins (intermolecular interactions) that couple the activity of this ion channel to additional cellular processes in epithelial cells (e.g. membrane traffic). Clarifying the nature of these interactions may lead to the development of novel strategies for treating diseases that involve the CFTR chloride channel. |
| Databáze: | OpenAIRE |
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