The effect of diet enriched with α-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients
| Autor: | Maria L Papaioannou, Loukianos S. Rallidis, Antonis Zampelas, Georgios K. Liakos, Georgios Anastasiadis, Georgios Paschos, Demosthenes B. Panagiotakos |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty food.ingredient Linolenic acid Linoleic acid Vascular Cell Adhesion Molecule-1 Blood lipids Hyperlipidemias Sensitivity and Specificity Statistics Nonparametric chemistry.chemical_compound food Linseed oil Reference Values Internal medicine E-selectin medicine Humans Unsaturated fatty acid Probability chemistry.chemical_classification biology Cell adhesion molecule Chemistry alpha-Linolenic Acid Middle Aged Intercellular Adhesion Molecule-1 Diet Endocrinology Biochemistry Dietary Supplements biology.protein E-Selectin Cardiology and Cardiovascular Medicine Follow-Up Studies Polyunsaturated fatty acid |
| Zdroj: | Atherosclerosis. 174:127-132 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2004.01.013 |
| Popis: | Background: Leukocyte adhesion and transendothelial migration, the critical pathogenic components in the development of atherosclerotic lesions, are largely mediated by cellular adhesion molecules (CAMs). We examined whether dietary supplementation with α-linolenic acid (ALA, 18:3 n −3) affects the levels of soluble forms of CAMs in dyslipidaemic patients. Methods: We recruited 90 male dyslipidaemic patients (mean age=51±8 years) following a typical Greek diet. They were randomly assigned either to 15ml of linseed oil (rich in ALA) per day ( n =60) or to 15ml of safflower oil (rich in linoleic acid [LA, 18:2 n −6]) per day ( n =30). The ratio of n −6: n −3 in linseed oil supplemented group was 1.3:1 and in safflower oil supplemented group 13.2:1. Dietary intervention lasted for 12 weeks. Blood lipids, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured. Results: Dietary supplementation with ALA significantly decreased sVCAM-1 levels (median decrease 18.7% [577.5ng/ml versus 487ng/ml, P =0.0001]). In the LA supplemented group, sVCAM-1 was also significantly decreased but to a lesser extent (median decrease 10.6% [550.5ng/ml versus 496ng/ml, P =0.0001]). After controlling for smoking habits, no significant difference was observed in the reduction of sVCAM-1 levels between the two treatment arms ( P =0.205). The decrease of sVCAM-1 was independent of lipid changes in both groups. Conclusions: Dietary supplementation with ALA for 12 weeks significantly decreases sVCAM-1 levels in dyslipidaemic patients. This effect presents a potential mechanism for the beneficial effect of plant n −3 polyunsaturated fatty acids in the prevention of coronary artery disease. In addition, dietary supplementation with LA significantly decreases sVCAM-1 levels, an effect which requires further investigation. |
| Databáze: | OpenAIRE |
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