Inflammatory cytokines following diethylcarbamazine (DEC) treatment of different clinical groups in lymphatic filariasis
| Autor: | M. Haarbrink, Maria Yazdanbakhsh, A. J. Terhell, Y. Mitsui, G.K. Abadi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Adolescent Helminthiasis Elephantiasis Diethylcarbamazine Brugia malayi Filariasis Proinflammatory cytokine Elephantiasis Filarial medicine Humans Child Lymphatic filariasis Aged Membrane Glycoproteins biology business.industry Tumor Necrosis Factor-alpha Interleukins Public Health Environmental and Occupational Health Interleukin General Medicine Middle Aged medicine.disease biology.organism_classification Infectious Diseases Filaricides Immunology Cytokines Parasitology Female business Carrier Proteins medicine.drug Acute-Phase Proteins |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 93(6) |
| ISSN: | 0035-9203 |
| Popis: | In an earlier study in Indonesia we reported on adverse reactions to diethylcarbamazine (DEC) in brugian filariasis patients identified as microfilaraemics (n = 26), endemic normals (n = 11) and elephantiasis patients (n = 17). To assess the link between adverse reactions and cytokines we have now analysed an array of inflammatory mediators in plasma samples collected during the same study. Pre-treatment levels of interleukin (IL)-6 and soluble tumour necrosis factor receptor 75 (sTNF-R75) were higher in elephantiasis patients compared to microfilaraemics and endemic normals, indicating the presence of an ongoing inflammation in patients with chronic disease. After initiation of treatment, the levels of IL-6 and LPS-binding protein (LBP) were consistently and significantly higher in microfilaraemics who suffered most from adverse reactions compared with endemic normals and elephantiasis patients. In microfilaraemics the levels of sTNF-R75 increased after treatment to reach levels recorded in elephantiasis patients. IL-6 increased early, concurrent with the development of adverse reactions and peaked by 24 h post treatment. The levels of LBP and sTNF-R75 in microfilaraemics also increased to peak, later than IL-6, at 32 h post DEC therapy. Although changes were recorded in IL-8 and IL-10 levels in some individuals, no significant differences were found between the 3 clinical groups. These results demonstrate that intake of DEC leads to an increase in a selected number of inflammatory mediators in the group of filarial patients who suffer most from adverse systemic reactions. |
| Databáze: | OpenAIRE |
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