Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor
| Autor: | Lili Xu, Guang Jian Liu, Yong Liu, Suiqiang Zhu, Li Ding, Yun-Fu Wang, Jingquan Hu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Research and Report mechanism Hippocampal formation Neuroprotection ischemia-reperfusion chemistry.chemical_compound Developmental Neuroscience Downregulation and upregulation medicine.artery Internal medicine medicine focal cerebral infarction nerve regeneration vascular endothelial growth factor Cerebral infarction business.industry brain injury protection medicine.disease Vascular endothelial growth factor medicine.anatomical_structure ischemic preconditioning chemistry transient ischemic attack Middle cerebral artery Cardiology Ischemic preconditioning infarct volume ratio neural regeneration business Neuroscience Artery |
| Zdroj: | Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction (2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|