Resting-state functional connectivity in medication-naïve adolescents with major depressive disorder
| Autor: | Ji Hyun Kim, Moon Soo Lee, Sang Il Suh, Jeonho Lee, InSeong Kim, Mani N. Pavuluri |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Rest Neuroscience (miscellaneous) Hippocampus Audiology behavioral disciplines and activities Amygdala Arousal 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Middle frontal gyrus Radiology Nuclear Medicine and imaging Prospective Studies Anterior cingulate cortex Cerebral Cortex Depressive Disorder Major Resting state fMRI business.industry medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure nervous system Adolescent Behavior Case-Control Studies Major depressive disorder Female Nerve Net business Insula 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research: Neuroimaging. 288:37-43 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2019.04.008 |
| Popis: | Adolescence is a vulnerable period for major depressive disorder (MDD). The aim of our study was to investigate resting-state functional connectivity (RSFC) in first-episode, medication-naïve adolescent MDD patients. Twenty-three drug-naïve adolescents diagnosed with first-episode MDD and 27 healthy participants were enrolled. Seed-to-voxel RSFC analyses were performed. The frontolimbic circuit regions of interest included the amygdala, anterior cingulate cortex, insula, and hippocampus. A correlation analysis between the RSFC and Children's Depression Inventory, Hamilton depression rating scale, and duration of episodes was performed. The adolescents with MDD exhibited the following characteristics: a lower RSFC between the right amygdala and right superior frontal gyrus; a lower RSFC between the right hippocampus and clusters including the right insula and right middle frontal gyrus; a higher RSFC between the left insula and clusters including the bilateral middle frontal gyrus, right superior frontal gyrus, and right frontal pole; and a higher RSFC between the left dorsal anterior cingulate cortex and a cluster including the left insula. Medication-naïve adolescents with depression display lower connectivity of several brain regions implicated in processing, regulation, and memory of emotions. Higher connectivity was observed in brain regions that potentially explain rumination, impaired concentration, and physiological arousal. |
| Databáze: | OpenAIRE |
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