Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population
| Autor: | Takeo Yoshikawa, Moinak Banerjee, Chandrashekharan M Nair, Priya M Allencherry, Neetha N Vijayan, Chandrasekhar Natarajan, Yoshimi Iwayama, Linda V. Koshy |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Linkage disequilibrium Genotype Population India Minisatellite Repeats Polymorphism Single Nucleotide Linkage Disequilibrium Genetics medicine Humans Allele education Genetics (clinical) Serotonin transporter Serotonin Plasma Membrane Transport Proteins education.field_of_study biology Haplotype Homozygote medicine.disease Haplotypes Schizophrenia Tandem Repeat Sequences Endophenotype Case-Control Studies biology.protein Female |
| Zdroj: | Journal of human genetics. 54(9) |
| ISSN: | 1435-232X |
| Popis: | Serotonin (5-hydroxytryptamine (5-HT)) transporter (SLC6A4) is known to influence mood, emotion, cognition and efficacy of antidepressants, particularly that of selective serotonin reuptake inhibitors. Atypical antipsychotics exert their effects partially through serotinergic systems, and hence, variation in 5-HT uptake may affect antipsychotic action mediated through the serotinergic system. Therefore, investigating the role of SLC6A4 as a risk factor for developing schizophrenia and treatment response had been a point of concern for many investigators, but with variable outcome. In this study, we examined the genetic roles of five polymorphisms of SLC6A4, including those of the widely studied 44 base pair variable number of tandem repeat (VNTR) in the promoter region of SLC6A4 (the serotonin transporter gene-linked polymorphic region: 5HTTLPR) and a VNTR polymorphism (STin2) in the second intron, in schizophrenia and its influence on the severity of symptoms in a South Indian population from Kerala, comprising 586 individuals. We detected significant allelic and genotypic associations with rs2066713 (both allelic and genotypic P-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|