Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population
| Autor: | Diana van Heemst, Kevin Mills, Fleur L. Meulmeester, Nadia Ashrafi, Frits R. Rosendaal, Raymond Noordam, Ko Willems van Dijk, Esther van Eekelen, Leon G. Martens, Renée de Mutsert, Jiao Luo, Dennis O. Mook-Kanamori |
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| Rok vydání: | 2020 |
| Předmět: |
lifestyle
Antioxidant Physiology Urinary system medicine.medical_treatment Clinical Biochemistry Population physical activity Alcohol vitamin E 030204 cardiovascular system & hematology Biochemistry Article smoking 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipid oxidation Medicine 030212 general & internal medicine sleep education Molecular Biology education.field_of_study alcohol business.industry Vitamin E lcsh:RM1-950 Cell Biology antioxidants lcsh:Therapeutics. Pharmacology Lifestyle factors chemistry Epidemiology of obesity diet business |
| Zdroj: | Antioxidants, Vol 9, Iss 1280, p 1280 (2020) Antioxidants, 9(12). MDPI Antioxidants Volume 9 Issue 12 |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox9121280 |
| Popis: | The antioxidant vitamin E (&alpha tocopherol, &alpha TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary &alpha tocopheronolactone hydroquinone (&alpha TLHQ) and &alpha carboxymethyl-hydroxychroman (&alpha CEHC levels), as potential reflection of lipid oxidation. We conducted a cross-sectional study in the Netherlands Epidemiology of Obesity Study. Serum &alpha TOH, and urinary &alpha TLHQ and &alpha CEHC were quantified by liquid chromatography coupled with tandem mass spectrometry. Information on the lifestyle factors (sleep, physical activity (PA), smoking and alcohol) were collected through questionnaires. Multivariable linear regression analyses were performed to assess the associations between the lifestyle factors and &alpha TOH measures. A total of 530 participants (46% men) were included with mean (SD) age of 56 (6) years. Of the examined lifestyle factors, only poor sleep was associated with a higher serum &alpha TOH (mean difference: 4% (95% CI: 1, 7%)). Current smoking was associated with higher urinary &alpha CEHC (32%: (14%, 53%)), with evidence of a dose&ndash response relationship with smoking intensity (low pack years, 24% (2, 52%) high pack years, 55% (25, 93%)). Moderate physical activity was associated with a lower &alpha TLHQ relative to &alpha CEHC (&minus 17%: (&minus 26, &minus 6%), compared with low PA). Only specific lifestyle factors associate with vitamin E metabolism. Examining serum &alpha TOH does not provide complete insight in vitamin E antioxidant capacity. |
| Databáze: | OpenAIRE |
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