Transposable element invasions
| Autor: | John F. Y. Brookfield, Elizabeth Hellen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
0106 biological sciences
Transposable element transposons Biology 010603 evolutionary biology 01 natural sciences Biochemistry Genome DNA sequencing 03 medical and health sciences chemistry.chemical_compound evolution Genetics mammals molecular dating 030304 developmental biology Sequence (medicine) 0303 health sciences Genetic diversity class II Common ancestry chemistry Evolutionary biology Commentary Mammalian genome DNA |
| Zdroj: | Mobile Genetic Elements |
| ISSN: | 2159-256X 2159-2543 |
| Popis: | Transposable elements have an ongoing, largely parasitic interaction with their hosts. We are interested in the timescale of this interaction. In a recent publication, we have examined the sequence divergence between class II DNA transposons from mammalian genomes. We asked whether these sequences undergo a continuing process of turnover, keeping a family as an integrated whole, as members of the family are continually created and lost. Alternatively, we envisaged that elements might have been involved in a burst of amplification, soon after they first occupied a mammalian genome, and the shared ancestry of present-day elements harks back to this initial amplification, a process that we termed a “life cycle.” We resolved between these processes by estimating the time to common ancestry predicted from the genetic diversity of sequences found in a transposon family, and also estimating, from the mammalian orders that currently possess copies of the family, the time when the family first entered the mammalian genome. These times are approximately the same, supporting the “life cycle” model. This casts light on how far we can infer genetic changes in the past through the study of DNA sequences from the present. |
| Databáze: | OpenAIRE |
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