MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement
| Autor: | T. Kainulainen, Aune Raustia, H. Pernu, Pertti Pirttiniemi, Petri Tiilikainen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Osteoarthritis Matrix metalloproteinase Condyle Pathology and Forensic Medicine stomatognathic system Arthropathy medicine Humans Aged Temporomandibular Joint business.industry Mandibular Condyle Anatomical pathology Anatomy Middle Aged Temporomandibular Joint Disorders medicine.disease Immunohistochemistry Temporomandibular joint stomatognathic diseases Derangement medicine.anatomical_structure Matrix Metalloproteinase 8 Otorhinolaryngology Periodontics Female Matrix Metalloproteinase 3 Oral Surgery business |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 34(1) |
| ISSN: | 0904-2512 |
| Popis: | Background: Internal derangement is one of the most common disorder of the temporomandibular joint (TMJ). The aim of this study was to investigate the associations of matrix metalloproteinase (MMP)-3 and -8 expression in articular condylar surface with different stages of TMJ internal derangement according to Wilkes (Minn Med, 1978; 61: 645–52) and osteoarthrosis (OA) according to Dijkgraaf et al. (J Oral Maxillofac Surg, 1995; 53: 1182–92). Methods: The study was based on 54 condylar specimens obtained during TMJ surgery. Immunohistochemistry using antibodies specific to MMP-3 and -8, represented in cartilage destruction, was carried out. Results: In all tissue specimens, MMP-3 expression was intense in the surface layer but showed less intensive staining in the deeper layers. Some MMP-8 expression was also seen. The severity of TMJ internal derangement, however, did not seem to have a statistically significant correlation (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text