Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results
| Autor: | Flavia di Michele, Augusto Pasini, Florian Holsboer, Andreas Ströhle, Gisela Gajewsky, Rainer Rupprecht, B. Hermann, Elena Romeo |
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| Rok vydání: | 2003 |
| Předmět: |
Male
double blind procedure eltanolone gas chromatography panic tranquilizing activity Pregnanolone Tetragastrin Placebos chemistry.chemical_compound Receptors anxiety disorder Gonadal Steroid Hormones pathophysiology mass spectrometry Cholecystokinin 4 aminobutyric acid A receptor clinical article article clinical trial Middle Aged 3alpha hydroxy 5alpha pregnan 20 one Settore MED/39 - Neuropsichiatria Infantile lactate sodium Psychiatry and Mental health neurosteroid Panic Disorder Female medicine.symptom Anxiety disorder Adult medicine.medical_specialty Neuroactive steroid medicine.drug_class progesterone Settore BIO/09 Anxiolytic Gas Chromatography-Mass Spectrometry Sodium Lactate Arts and Humanities (miscellaneous) Internal medicine excitability mental disorders medicine Humans controlled study human controlled clinical trial GABA-A business.industry Panic disorder disease association Allopregnanolone Panic central nervous system medicine.disease Receptors GABA-A steroid blood level Endocrinology chemistry concentration response randomized controlled trial placebo tetragastrin adult female male business |
| Zdroj: | Archives of general psychiatry. 60(2) |
| ISSN: | 0003-990X |
| Popis: | Certain metabolites of progesterone such as 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP; allopregnanolone) and 3alpha,5beta-THP (pregnanolone) are potent, positive allosteric modulators of gamma-aminobutyric acid type A receptors. Although animal studies suggest anxiolytic properties of these endogenous modulators of central nervous excitability, no clinical data indicate whether they are also involved in the pathophysiology of anxiety disorders and panic attacks.We quantified the concentrations of 3alpha,5alpha-THP, 3alpha,5beta-THP, the isomer 3beta,5alpha-THP, and their precursors in the plasma of 10 patients with panic disorder and matched control subjects during panic attacks induced by means of sodium lactate and cholecystokinin tetrapeptide administration, using a highly sensitive gas chromatography-mass spectrometry analysis.Panic attacks induced by sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder were accompanied by pronounced decreases in the concentrations of 3alpha,5alpha-THP and 3alpha,5beta-THP and a concomitant increase in the concentrations of the functional antagonistic isomer 3beta,5alpha-THP, findings that are compatible with a decreased gamma-aminobutyric acid-ergic tone. No changes in neuroactive steroid concentrations were observed after placebo administration in patients with panic disorder or after placebo, sodium lactate, or cholecystokinin tetrapeptide administration in controls.The association between changes in plasma neuroactive steroid concentrations and experimentally induced panic attacks and the well-documented pharmacological properties of these compounds as gamma-aminobutyric acid type A receptor modulators suggest that neuroactive steroids may play a role in the pathophysiology of panic attacks in patients with panic disorder. |
| Databáze: | OpenAIRE |
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