Effects of combination of Caiapo with other plant-derived substance on anti-diabetic efficacy in KK-Ay mice
| Autor: | Syuichi Kusano, Yasuhide Sakuramata, Hiromi Oe, Osami Aki |
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| Rok vydání: | 2005 |
| Předmět: |
Single administration
Blood Glucose Combination therapy Clinical Biochemistry Mice Inbred Strains Ipomoea Biochemistry Plant Roots law.invention Mice Animal science Insulin resistance law Diabetes mellitus Botany medicine Animals Humans Hypoglycemic Agents Kk ay mice Glucose tolerance test medicine.diagnostic_test biology Chemistry General Medicine Glucose Tolerance Test medicine.disease biology.organism_classification Plant Leaves Disease Models Animal Diabetes Mellitus Type 2 Molecular Medicine Insulin Resistance Phytotherapy |
| Zdroj: | BioFactors (Oxford, England). 22(1-4) |
| ISSN: | 0951-6433 |
| Popis: | B. Ludvik et al., have recently shown the effect of Caiapo (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type-2 diabetic patients. It, however, was required 2-4 weeks after the single administration of Caiapo. The present study aimed to determine if the combination therapy of Caiapo with a mulberry leaf powder, which inhibits alpha-glucosidase, or with a loquat leaf extract, which shows an insulin-like effect, could make it possible to enhance the antidiabetic activities of Caiapo, and to shorten the time necessary for the inhibition of increasing blood glucose levels. A mixture of the pulverized tuber of Caiapo (357 mg/kg) and the mulberry leaf powder (143 mg/kg), or a mixture of the pulverized skin of Caiapo (194 mg/kg) and the powdered loquat leaf extract (6 mg/kg) was orally administered to 6 weeks-old male KK-Ay mice for 28 days and the glucose loading test was conducted every 7 days. In the glucose loading test after one week feeding, a reduction in blood glucose concentration after 60 minutes of the administration of glucose was observed in both mixture groups against the control group (p < 0.05) in the case of Caiapo only, similar delayed effects were seen in 2-3 weeks after feeding. |
| Databáze: | OpenAIRE |
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