Treatment of superficial vein thrombosis with intermediate dose of tinzaparin: A real word cohort study – The SeVEN EXTension study
| Autor: | Christos Karathanos, Athanasios D. Giannoukas, Ioannis Papakostas, Konstantinos Goumas, Panagiotis Latzios, Dimitrios Chatzis |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Superficial vein thrombosis medicine.drug_class Low molecular weight heparin 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences Tinzaparin 0302 clinical medicine medicine Humans 030212 general & internal medicine Venous Thrombosis business.industry Extension study Anticoagulants Thrombosis General Medicine Heparin Low-Molecular-Weight medicine.disease Pulmonary embolism Treatment Outcome Observational study Real word Radiology Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Phlebology: The Journal of Venous Disease. 36:423-431 |
| ISSN: | 1758-1125 0268-3555 |
| DOI: | 10.1177/0268355520947300 |
| Popis: | Background To assess the treatment of superficial vein thrombosis (SVT) with intermediate dose of tinzaparin in a setting of real world practice. Methods Prospective observational study of consecutive patients treated by vascular physicians in the private sector with tinzaparin (131 IU/Kg) once daily. Treatment duration was at the treating physician’s discretion. The outcomes of the study were symptomatic venous thromboembolism, extension of thrombus and bleeding complications. Results 660 patients were included and followed up for at least 3 months. Median duration of treatment was 30 days (14–120). History of prior deep vein thrombosis (HR 2.77; 95% CI= 1.18–6.49; p = 0.018) and current SVT above the knee (HR1.84; 95% CI = 1.33–3.53; p = 0.0002) were associated with prolonged treatment duration. Primary efficacy outcomes occurred in 20 (3%) patients. The median time to the event was 24 (6–92) days and was not related to treatment duration. Conclusions Tinzaparin at intermediate dose is an effective and safe treatment for SVT. |
| Databáze: | OpenAIRE |
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