Pathogenesis of the B variant of encephalomyocarditis virus
| Autor: | Raheel Shafi, David J. Giron, Delie Roselyn Cerutis |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Nervous system
Male viruses Central nervous system Blood–brain barrier Virus Replication Virus Cell Line Pathogenesis Mice Virology medicine Enterovirus Infections Animals Encephalomyocarditis virus Pancreas Mice Inbred ICR biology Brain Heart biology.organism_classification medicine.disease Cardiovirus Infectious Diseases medicine.anatomical_structure Organ Specificity Immunology Viral disease Encephalitis |
| Zdroj: | Journal of medical virology. 40(3) |
| ISSN: | 0146-6615 |
| Popis: | Variants of encephalomyocarditis virus (EMCV) are immunologically indistinguishable by hyperimmune serum, but, with the exception of EMCV-B, each produces a different disease syndrome and infects the central nervous system in mice infected via the intraperitoneal route of inoculation. The B variant is benign in that it does not produce any overt signs of infection at doses as high as 106 pfu per animal. The present study was carried out to determine if EMCV-B was pathogenic when administered via the intracranial route and, if so, to delineate the area(s) of the brain infected. The results show that, when given i.c., EMCV-B is similar to other variants of EMCV in that it infects and replicates in the brain, causing encephalitis, neuronal necrosis in Ammon's horn of the hippocampus, and clinical signs of infection. The data indicate that receptor sites for EMCV-B are present on brain cells and suggest that its benign nature when given by the intraperitoneal route reflects an inability to cross the blood-brain barrier. © 1993 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text