The Simultaneous Elevation of Oxidative Stress Markers and Wilms' Tumor 1 Gene during the Progression of Myelodysplastic Syndrome
| Autor: | Ichiro Tatsuno, Naomi Shimizu, Youichi Iwashita, Hiromitsu Yokota, Hidekazu Hasunuma, Yasuhiro Watanabe, Yasuo Matsuzawa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Antimetabolites Antineoplastic Chest Pain azacitidine Genes Wilms Tumor Iron Overload DNA damage Multiple Organ Failure Azacitidine Siderophores Case Report Oxidative phosphorylation Deferoxamine medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Fatal Outcome Wilms' Tumor 1 (WT1) Internal Medicine Biomarkers Tumor Medicine Humans Gene Aged biology business.industry ferritin Wilms' tumor General Medicine medicine.disease Peripheral blood myelodysplastic syndrome Ferritin Oxidative Stress 030104 developmental biology 030220 oncology & carcinogenesis Myelodysplastic Syndromes Immunology Ferritins biology.protein Cancer research Disease Progression business Oxidative stress medicine.drug DNA Damage |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Oxidative stress is closely related to iron overload in myelodysplastic syndrome (MDS) and induces DNA damage. We evaluated the oxidative stress markers derivatives of reactive oxidative metabolites (dROM) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) during azacitidine treatment in an MDS patient. Simultaneous with an increase in the expression of Wilms' Tumor 1 (WT1) gene in the peripheral blood, the serum dROM level was elevated, and this increase was observed earlier than the increases in ferritin and 8-OHdG. Throughout the clinical course, dROM and 8-OHdG correlated significantly with WT1 and with ferritin, suggesting that changes in the oxidative stress marker levels reflect not only iron overload but also disease progression of MDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|