Two-photon imaging with silicon photomultipliers

Autor:	Kaspar Podgorski, Mehrab N Modi, Glenn C. Turner, Kayvon Daie
Rok vydání:	2019
Předmět:	Physics Photomultiplier Neural activity Photon Optics Silicon photomultiplier Two-photon excitation microscopy business.industry Medical imaging business Atomic and Molecular Physics and Optics Pulse height Voltage
Zdroj:	Optics express. 27(24)
ISSN:	1094-4087
Popis:	We compared performance of recently developed silicon photomultipliers (SiPMs) to GaAsP photomultiplier tubes (PMTs) for two-photon imaging of neural activity. Despite higher dark counts, SiPMs match or exceed the signal-to-noise ratio of PMTs at photon rates encountered in typical calcium imaging experiments due to their low pulse height variability. At higher photon rates encountered during high-speed voltage imaging, SiPMs substantially outperform PMTs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38b1c26d09ed23bb8a704c3b9578ee2 https://pubmed.ncbi.nlm.nih.gov/31878749 Zobrazit plný text záznamu