APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease

Autor: Yi-Ge Yang, Xinrui Yuan, Caiyou Hu, Wen-yu Jiang, Ze Yang, Guofang Pang, Zeping Lv, Shenghang Pang, Wandong Zhang, Xiaohong Shi, Dantao Peng, Qin Zhou, Haiqun Xie, Chu-yu Yang
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Gerontology
Oncology
Apolipoprotein E
cognition
genotype
polymerase chain reaction
nerve degeneration
Disease
polymorphism
gel electrophoresis
Polymorphism (computer science)
cognitive defect
Cognitive decline
NSFC grant
DNA extraction
restriction fragment length polymorphism
apolipoprotein E
disease course
longitudinal study
Cognition
Alzheimer's disease
cohort analysis
aged
female
cognitive disorders
lipids (amino acids
peptides
and proteins)
Alzheimer disease
neural regeneration
apolipoprotein CI gene
medicine.medical_specialty
apolipoprotein CI
apolipoprotein E gene
Clinical Dementia Rating
gene frequency
Clinical Practice
Developmental Neuroscience
male
Internal medicine
medicine
Dementia
follow up
gene
Allele frequency
outcome assessment
business.industry
gene interaction
disease association
scoring system
medicine.disease
low density lipoprotein receptor related protein gene
major clinical study
low density lipoprotein receptor-related protein
ultraviolet spectrophotometry
DNA polymorphism
business
dementia
rating scale
Zdroj: Neural Regeneration Research
DOI: 10.4103/1673-5374.130117
Popis: Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE e4 carriers compared with non-carriers. In addition, the APOE e4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE e4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
Databáze: OpenAIRE
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