Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis
| Autor: | Yaovaluk Chamgramol, Chawalit Pairojkul, Thidarut Boonmars, Watchalin Loilome, Pranee Sriraj, Amornrat Juasook, Orasa Wonkchalee, Kulthida Vaeteewoottacharn, Chantana Aromdee, Watcharee Khunkitti, Porntip Laummaunwai, Zhiliang Wu, Ratchadawan Aukkanimart, Pakkayanee Sudsarn |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Opisthorchiasis Antioxidants Anti-inflammatory Acanthaceae Cricetinae parasitic diseases medicine Animals Urea Opisthorchis viverrini Blood urea nitrogen Anthelmintics Microscopy Mesocricetus General Veterinary biology medicine.diagnostic_test Traditional medicine Histocytochemistry Plant Extracts Alanine Transaminase General Medicine Alkaline Phosphatase biology.organism_classification Thunbergia laurifolia Disease Models Animal Treatment Outcome Infectious Diseases Liver Alanine transaminase Creatinine Insect Science biology.protein Alkaline phosphatase Parasitology Liver function tests |
| Zdroj: | Parasitology Research. 111:353-359 |
| ISSN: | 1432-1955 0932-0113 |
| Popis: | Thunbergia laurifolia Linn (Rang Chuet) possesses antioxidant and anti-inflammatory properties as well as anticancer activities. The aim of the present study was to evaluate the efficacy of T. laurifolia in reducing inflammation from pathological changes in Syrian hamsters infected with the human liver fluke Opisthorchis viverrini. Hamster groups were also administered N-nitrosodimethylamine (NDMA) and treated with T. laurifolia. Light microscopic observation of histopathological changes, liver function tests for alanine transaminase (ALT) and alkaline phosphatase (ALP) and kidney function tests for blood urea nitrogen (BUN) and creatinine were performed. Antioxidant effects of both fresh and dried Rang Chuet solutions were observed. Analysis of the histopathological changes showed anti-inflammatory properties, both in the case of O. viverrini infection or with NDMA administration, by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts as indicated by normal serum ALT, ALP, BUN and creatinine levels in treated Syrian hamsters. The present study found that fresh and dried Rang Chuet solutions clearly reduced the inflammatory cells in both O. viverrini-infected and NDMA-administered groups and was correlated with the total antioxidant capacity. These findings suggest that T. laurifolia possesses antioxidant and anti-inflammatory properties and that its application may be useful for prevention of the inflammatory process, one of the risk factors of O. viverrini-associated cholangiocarcinoma (CCA). |
| Databáze: | OpenAIRE |
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