Bovine Milk Lymphocytes Display the Phenotype of Memory T Cells and Are Predominantly CD8+
| Autor: | James S Cullor, Jeffrey L Stott, J. D. Dellinger, Bernadette C. Taylor |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte medicine.drug_class Lymphocyte Immunology Population Biology Monoclonal antibody Flow cytometry Andrology Antigen Antigens CD T-Lymphocyte Subsets Lactation medicine Animals education education.field_of_study medicine.diagnostic_test T-cell receptor food and beverages Milk medicine.anatomical_structure Cattle Female Immunologic Memory CD8 |
| Zdroj: | Cellular Immunology. 156:245-253 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.1994.1169 |
| Popis: | The phenotype of bovine milk lymphocytes was investigated and compared to peripheral blood lymphocytes using monoclonal antibodies specific for bovine leukocyte differentiation antigens and flow cytometry. T Lymphocytes traffic selectively into bovine milk while B lymphocytes represent a minor population in milk by comparison to peripheral blood. The vast majority of T cells in milk express αβ T cell receptors and are predominantly CD8 + . T cells in milk express twofold higher levels of CD2 and fivefold lower levels of CD45R, characteristics associated with memory T cells. Grouping of cows by lactational stage and analysis of lymphocyte subpopulation percentages indicated that CD4 + T cells are present in relatively low numbers in milk of cows in the first 50 days of lactation and have a significant tendency to increase in number as lactation progresses. |
| Databáze: | OpenAIRE |
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