The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome
| Autor: | Andrew C. Warren, Effrosini P. Economou, Andrew W. Bergen, Stylianos E. Antonarakis |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Genetics Polymorphism Genetic Multidisciplinary Base Sequence Genome Human Pseudogene Molecular Sequence Data Gene Amplification Alu element Biology DNA sequencing Pedigree genomic DNA Humans Female Human genome Restriction fragment length polymorphism Oligonucleotide Probes Poly A Repeated sequence Gene Alleles Repetitive Sequences Nucleic Acid Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 87:2951-2954 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.87.8.2951 |
| Popis: | To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the beta-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome. |
| Databáze: | OpenAIRE |
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