Nerve Growth Factor Receptor Immunolocalization During Human Palate and Tongue Development
| Autor: | Inger Kjær, Birgit Fischer-Hansen, Dorrit Nolting, Takashi Ono |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Biology Receptor Nerve Growth Factor Embryonic and Fetal Development 03 medical and health sciences 0302 clinical medicine Tongue medicine Humans 030223 otorhinolaryngology Fetus Bone decalcification Palate Growth factor Antibodies Monoclonal Soft tissue 030206 dentistry Anatomy Immunohistochemistry Staining medicine.anatomical_structure Nerve growth factor Otorhinolaryngology Oral Surgery |
| Zdroj: | The Cleft Palate-Craniofacial Journal. 40:116-125 |
| ISSN: | 1545-1569 1055-6656 |
| DOI: | 10.1597/1545-1569(2003)040<0116:ngfrid>2.0.co;2 |
| Popis: | ObjectiveTo investigate the temporospatial pattern of nerve growth factor receptor (NGFR) immunolocalization during human palatal closure.MaterialsHuman palate and tongue tissues from 33 embryos/fetuses, 9 to 22 weeks of fertilization age.MethodsTissues were divided according to developmental stage and palatal development (before, during, and after closure) and then subjected to decalcification, paraffin embedding, serial sectioning, survey staining, and p75NGFR immunohistochemical staining.ResultsSpecific temporospatial patterns of p75NGFR reactivity were observed; reactivity was intense in the soft tissue palatal shelves before and during palatal closure and was weaker in the palate after palatal closure. In the tongue, intense reactivity was seen throughout 9 to 22 weeks.ConclusionThe observed patterns suggest that p75NGFR may enable the visualization of physiological events in palatal closure during normal human development. |
| Databáze: | OpenAIRE |
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