Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances
| Autor: | Karla L. Miller, Alard Roebroeck, Manisha Aggarwal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Computer science
HUMAN CONNECTOME PROJECT STATE FREE PRECESSION Special Issue Review Articles FORMALIN FIXATION Tissue Preparation 030218 nuclear medicine & medical imaging diffusion MRI 03 medical and health sciences 0302 clinical medicine medicine Journal Article Humans Radiology Nuclear Medicine and imaging POSTMORTEM HUMAN BRAINS Spectroscopy IN-VIVO Visual Cortex validation Human Connectome Project HISTOLOGICAL VALIDATION WATER RELAXATION Brain cortical layers Human brain WEIGHTED MRI Special Issue Review Article gray matter Important research medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging ex vivo Molecular Medicine STRUCTURE TENSOR ANALYSIS SPIN-ECHO Neuroscience white matter 030217 neurology & neurosurgery Ex vivo Diffusion MRI |
| Zdroj: | Nmr in Biomedicine NMR in Biomedicine |
| DOI: | 10.1002/nbm.3941 |
| Popis: | This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on the human brain. We review the challenges posed by the properties of post-mortem tissue, and discuss state-of-the-art tissue preparation methods and recent advances in pulse sequences and acquisition techniques to tackle these. We then review recent ex vivo dMRI studies of the human brain, highlighting the validation of white matter orientation estimates and the atlasing and mapping of large subcortical structures. We also give particular emphasis to the delineation of layered gray matter structure with ex vivo dMRI, as this application illustrates the strength of its mesoscale resolution over large fields of view. We end with a discussion and outlook on future and potential directions of the field. |
| Databáze: | OpenAIRE |
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