Surgical Approach to Recurrent Cholangiocarcinoma
| Autor: | Hauke Lang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Surgical approach Standard of care business.industry Tumor biology Systemic chemotherapy General surgery Gastroenterology Review Article 030230 surgery Resection 03 medical and health sciences 0302 clinical medicine Medicine 030211 gastroenterology & hepatology Surgery Recurrent Cholangiocarcinoma business Surgical treatment Intrahepatic Cholangiocarcinoma |
| Zdroj: | Visc Med |
| ISSN: | 2297-4725 |
| Popis: | Background: For recurrent cholangiocarcinoma, systemic chemotherapy is the standard of care. Repeated resection is a potential curative treatment, but data are scarce and outcomes are not well defined so far. Summary: In the last decade there has been an increasing number of reports suggesting a survival benefit and even cure after repeated surgery. This is particularly true for intrahepatic cholangiocarcinoma, where repeated resections offer similar or even better results than the first resection. In selected cases even a third liver resection is possible. In contrast, in perihilar and distal cholangiocarcinoma, repeated resection is only rarely possible. Although the improved outcome might be attributed to a careful patient selection and a favorable tumor biology, repeated surgical treatment should be attempted whenever possible. This necessitates a structured follow-up after resection. Key Message: Surgical resection offers the chance for prolonged survival and even for cure in recurrent cholangiocarcinoma. Hence, it is of the utmost importance to better understand the routes of metastases and to define factors qualifying for resection. Whether different patterns of recurrence reflect biological heterogeneity requires further investigation. |
| Databáze: | OpenAIRE |
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