Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia

Autor:	Marry M. van den Heuvel-Eibrink, Saskia M F Pluijm, Rob Pieters, Marissa A. H. den Hoed, André G. Uitterlinden
Přispěvatelé:	Pediatrics, Internal Medicine
Rok vydání:	2016
Předmět:	Genetic Markers Oncology Asparaginase medicine.medical_specialty Bone Morphogenetic Protein 7 Medical laboratory Genome-wide association study Disease Models Biological Polymorphism Single Nucleotide Receptors N-Methyl-D-Aspartate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacotherapy Risk Factors Internal medicine Plasminogen Activator Inhibitor 1 Genetics medicine Humans Child Genetic association Homeodomain Proteins Pharmacology business.industry Tumor Suppressor Proteins Osteonecrosis General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Human genetics chemistry 030220 oncology & carcinogenesis Physical therapy Molecular Medicine business Complication Genome-Wide Association Study 030215 immunology
Zdroj:	Molecular Diagnosis & Therapy, 20(6), 519-522. Adis
ISSN:	1177-1062
Popis:	Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been identified as being associated with osteonecrosis; however, a prediction model that combines pretreatment genetic biomarkers and clinical factors has not yet been designed. Such a prediction model can only be developed with continuing international collaborations and research efforts, including large genome-wide association studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38332b30d689ed2c362ecd71a55c897 https://pure.eur.nl/en/publications/402260a4-6602-4aa0-9632-c7636c9ad77f Zobrazit plný text záznamu Full text from SpringerLink