Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population
| Autor: | Andrey V. Barkhash, A. G. Romaschenko, Mikhail I. Voevoda, Vladimir N. Babenko |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genotype Single-nucleotide polymorphism Polymorphism Single Nucleotide Microbiology Russia 03 medical and health sciences Flaviviridae Gene Frequency Genetic predisposition medicine Humans Genetic Predisposition to Disease Allele frequency Alleles Genetics 030102 biochemistry & molecular biology biology Interleukins Tick-borne encephalitis medicine.disease biology.organism_classification Interleukin-10 030104 developmental biology Infectious Diseases Interleukin 28B Insect Science Immunology Parasitology Interferons Gene polymorphism Encephalitis Tick-Borne |
| Zdroj: | Ticks and Tick-borne Diseases. 7:808-812 |
| ISSN: | 1877-959X |
| DOI: | 10.1016/j.ttbdis.2016.03.019 |
| Popis: | Genetic predisposition to tick-borne encephalitis (TBE) is rather poorly studied in human populations. Human genes encoding crucial components of antiviral immune response are most likely involved in protective mechanisms against TBE virus. Previously, several single nucleotide polymorphisms (SNPs) located in interleukin 28B (IL28B) and interleukin 10 (IL10) genes were associated with predisposition to chronic hepatitis C (caused by a structurally similar virus from the same Flaviviridae family) in a number of human populations. The aim of the present study was to estimate a possible association of the IL28B gene rs8103142 and rs12980275 SNPs and IL10 gene rs1800872, rs3021094, and rs3024498 SNPs with predisposition to TBE in a Russian population. Genotypic and allelic frequencies for these SNPs were analyzed in 132 non-immunized TBE patients (34 with fever, 60 with meningitis, and 38 with severe central nervous system disease) and compared with the population control (221 Novosibirsk citizens). The results obtained suggest that both studied IL28B gene SNPs, as well as the IL10 gene rs1800872 SNP are associated with predisposition to TBE in Russian population. |
| Databáze: | OpenAIRE |
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