Strength retention of self-reinforced drawn poly-L/DL-lactide 70/30 (SR-PLA70) rods and fixation properties of distal femoral osteotomies with these rods. An experimental study on rats

Autor:	Harri Pihlajamäki, Hannu Pätiälä, Pentti Rokkanen, Janne Viljanen, Nureddin Ashammakhi, Minna Kellomäki, Antti Joukainen, E. Antero Mäkelä, P. Törmälä
Rok vydání:	2000
Předmět:	Male medicine.medical_specialty Time Factors Materials science Polymers Polyesters Biomedical Engineering Biophysics Bioengineering Mechanics Rod Self reinforced Biomaterials Distal femur chemistry.chemical_compound Flexural strength Materials Testing medicine Postoperative infection Animals Femur Lactic Acid Rats Wistar Fixation (histology) Lactide business.industry Flexural modulus Prostheses and Implants Osteotomy Rats Surgery Radiography chemistry Female Nuclear medicine business
Zdroj:	Journal of Biomaterials Science, Polymer Edition. 11:1411-1428
ISSN:	1568-5624 0920-5063
Popis:	Self-reinforced polylevo-dextro-lactic acid (SR-PLA) 70 composite rods, (2 mm x 26 mm) were implanted in the dorsal subcutaneus tissue of sixteen rats. Osteotomies of the distal femur were fixed with SR-PLA70 composite rods (2 mm x 15 mm) in 39 rats. The follow-up times varied from 1 week to 1 year. After sacrifice three-point bending and shear tests were performed for subcutaneously placed rods, and radiological, histological, histomorphometrical, microradiographic, and oxytetracycline-fluorescence studies of osteotomized and intact control femora were performed. At 52 weeks the shear strength and flexural modulus of the rods were 41% of the initial value, and the flexural strength was 43% of the initial value. In the osteotomies seven specimens had to be excluded due to postoperative infection or dislocation of the fragment. Six of the thirty-two evaluated osteotomies showed signs of postoperative infection. Twenty-six osteotomies healed uneventfully. No signs of inflammatory or foreign-body reaction were observed. The present investigation demonstrated that the mechanical strength and fixation properties of the SR-PLA70 rods are suitable for fixation of cancellous bone osteotomies in rats. The present article is the first report on successful application of SR-PLA70 rods for fixation of cancellous bone osteotomies studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a381e7b34647eb2c5c1dbb1ce7627f68 https://doi.org/10.1163/156856200744318 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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