Recent Insights on Alzheimer’s Disease Originating from Yeast Models

Autor: Daniel P. Mulvihill, Melody Cools, Jimmy Beckers, Joke Verelst, David Seynnaeve, Joris Winderickx, Gernot Fruhmann, Mara Del Vecchio, Vanessa Franssens
Rok vydání: 2018
Předmět:
0301 basic medicine
GAMMA-SECRETASE
Chemistry
Multidisciplinary
Review
yeast
MICROTUBULE-ASSOCIATED PROTEINS
lcsh:Chemistry
Kluyveromyces
0302 clinical medicine
Ubiquitin
OXIDATIVE STRESS
lcsh:QH301-705.5
Spectroscopy
Kluyveromyces lactis
TAU-PROTEIN
biology
PAIRED HELICAL FILAMENTS
aggregation
General Medicine
Alzheimer's disease
Computer Science Applications
AMYLOID PRECURSOR PROTEIN
Chemistry
Physical Sciences
amyloid β
Life Sciences & Biomedicine
Alzheimer’s disease
Biochemistry & Molecular Biology
Saccharomyces cerevisiae
tau Proteins
Computational biology
Models
Biological
Catalysis
oligomerization
prion
Inorganic Chemistry
03 medical and health sciences
Alzheimer Disease
ubiquitin
Schizosaccharomyces
Animals
Humans
Protein oligomerization
Physical and Theoretical Chemistry
Molecular Biology
Science & Technology
Amyloid beta-Peptides
Candida glabrata
Organic Chemistry
IN-VITRO
FRONTOTEMPORAL DEMENTIA
biology.organism_classification
Yeast
amyloid beta
030104 developmental biology
Proteostasis
lcsh:Biology (General)
lcsh:QD1-999
Schizosaccharomyces pombe
biology.protein
PROLYL ISOMERASE PIN1
Tau
BRAIN A-BETA
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1947 (2018)
ISSN: 1422-0067
Popis: In this review article, yeast model-based research advances regarding the role of Amyloid-β (Aβ), Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown their added value as complementary models for the study of the molecular aspects of these proteins, including their interplay with AD-related cellular processes such as mitochondrial dysfunction and altered proteostasis. Moreover, these yeast models have also shown their importance in translational research, e.g., in compound screenings and for AD diagnostics development. In addition to well-established Saccharomyces cerevisiae models, new upcoming Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for Aβ and Tau are briefly described. Finally, traditional and more innovative research methodologies, e.g., for studying protein oligomerization/aggregation, are highlighted. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:19 issue:7 ispartof: location:Switzerland status: published
Databáze: OpenAIRE
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