Recent Insights on Alzheimer’s Disease Originating from Yeast Models
Autor: | Daniel P. Mulvihill, Melody Cools, Jimmy Beckers, Joke Verelst, David Seynnaeve, Joris Winderickx, Gernot Fruhmann, Mara Del Vecchio, Vanessa Franssens |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
GAMMA-SECRETASE Chemistry Multidisciplinary Review yeast MICROTUBULE-ASSOCIATED PROTEINS lcsh:Chemistry Kluyveromyces 0302 clinical medicine Ubiquitin OXIDATIVE STRESS lcsh:QH301-705.5 Spectroscopy Kluyveromyces lactis TAU-PROTEIN biology PAIRED HELICAL FILAMENTS aggregation General Medicine Alzheimer's disease Computer Science Applications AMYLOID PRECURSOR PROTEIN Chemistry Physical Sciences amyloid β Life Sciences & Biomedicine Alzheimer’s disease Biochemistry & Molecular Biology Saccharomyces cerevisiae tau Proteins Computational biology Models Biological Catalysis oligomerization prion Inorganic Chemistry 03 medical and health sciences Alzheimer Disease ubiquitin Schizosaccharomyces Animals Humans Protein oligomerization Physical and Theoretical Chemistry Molecular Biology Science & Technology Amyloid beta-Peptides Candida glabrata Organic Chemistry IN-VITRO FRONTOTEMPORAL DEMENTIA biology.organism_classification Yeast amyloid beta 030104 developmental biology Proteostasis lcsh:Biology (General) lcsh:QD1-999 Schizosaccharomyces pombe biology.protein PROLYL ISOMERASE PIN1 Tau BRAIN A-BETA 030217 neurology & neurosurgery |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 7, p 1947 (2018) |
ISSN: | 1422-0067 |
Popis: | In this review article, yeast model-based research advances regarding the role of Amyloid-β (Aβ), Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown their added value as complementary models for the study of the molecular aspects of these proteins, including their interplay with AD-related cellular processes such as mitochondrial dysfunction and altered proteostasis. Moreover, these yeast models have also shown their importance in translational research, e.g., in compound screenings and for AD diagnostics development. In addition to well-established Saccharomyces cerevisiae models, new upcoming Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for Aβ and Tau are briefly described. Finally, traditional and more innovative research methodologies, e.g., for studying protein oligomerization/aggregation, are highlighted. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:19 issue:7 ispartof: location:Switzerland status: published |
Databáze: | OpenAIRE |
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