Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats
| Autor: | Hasan Hüseyin Demirel, Hidayet Yavuz, Mustafa Kabu, Sinan Ince, Ruhi Türkmen, Yavuz Osman Birdane |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Glycine Administration Oral 010501 environmental sciences Pharmacology Kidney medicine.disease_cause 01 natural sciences Median lethal dose Antioxidants Acetylcysteine chemistry.chemical_compound medicine Animals Environmental Chemistry Rats Wistar 0105 earth and related environmental sciences chemistry.chemical_classification Dose-Response Relationship Drug Herbicides Toxicity Tests Subchronic General Medicine Glutathione Malondialdehyde Pollution Rats Oxidative Stress medicine.anatomical_structure Liver chemistry Cytoprotection Thiol Oxidative stress medicine.drug |
| Zdroj: | Environmental Science and Pollution Research. 26:11427-11437 |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | It is claimed that oxidative stress has a prominent role in the mechanism of toxic effects formed by glyphosate-based herbicide (GBH) in living systems. A strong thiol compound, N-acetylcysteine (NAC), has antioxidative and cytoprotective properties. The objective in this subchronic toxicity study was to identify the prophylactic effect of NAC over histopathological changes and oxidative stress induced by GBH in blood, renal, liver, cardiac, and brain tissues. A sum of 28 male Wistar rats were divided into four equal groups, each containing 7 rats. During the study, group I (control group) was supplied with normal rodent bait and tap water ad libitum. The applied agents were 160 mg/kg NAC to group II, 375 mg/kg as equivalent to 1/10 of lethal dose 50% (LD50) of GBH to group III, and 160 mg/kg of NAC and 375 mg/kg of GBH together once per day as oral gavage to group IV for 8 weeks. While GBH decreased the levels of GSH in blood, liver, kidney, and brain tissues, it considerably increased malondialdehyde levels. On the contrary, these parameters happened to improve in the group supplied with NAC. Besides, it was seen that NAC was observed to improve the histopathologic changes in rat tissues induced by GBH. It was concluded that NAC protects oxidative stress and tissue damage induced by GBH in blood and tissue and this prophylactic effect could be attributed to its antioxidant and free radical sweeper character. |
| Databáze: | OpenAIRE |
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