Current scenario of indole derivatives with potential anti-drug-resistant cancer activity
| Autor: | Yufeng Gong, Xuefeng Wang, Xiaoyue Wen, Yanshu Jia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indoles
Antineoplastic Agents Drug resistance Vinorelbine 01 natural sciences Structure-Activity Relationship 03 medical and health sciences Drug Discovery medicine Humans Semaxanib 030304 developmental biology Pharmacology Indole test 0303 health sciences 010405 organic chemistry Chemistry Sunitinib Organic Chemistry Cancer General Medicine medicine.disease 0104 chemical sciences Vinblastine Drug Resistance Neoplasm Drug Design Cancer cell Cancer research medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 200:112359 |
| ISSN: | 0223-5234 |
| Popis: | Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment. Indole derivatives have the potential to act on diverse targets in cancer cells and exhibit promising activity against drug-resistant cancers. Moreover, some indole-containing compounds such as Semaxanib, Sunitinib, Vinorelbine, and Vinblastine have already been applied in clinics for various kinds of cancer even drug-resistant cancer therapy. Thus, indole derivatives are one of significant resources for the development of novel anti-drug-resistant cancer agents. This review focuses on the recent development of indole derivatives with potential therapeutic application for drug-resistant cancers, and the mechanisms of action, the critical aspects of design as well as structure-activity relationships, covering articles published from 2010 to 2020. |
| Databáze: | OpenAIRE |
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