Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
| Autor: | Aida Kistaubayeva, Irina Savitskaya, D. H. Shokatayeva, L. V. Ignatova, Ilya Digel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Wound healing Bacillus subtilis medicine.disease_cause Microbiology Microbial biotechnology Bacterial cellulose 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Staphylococcus epidermidis medicine lcsh:Social sciences (General) lcsh:Science (General) Escherichia coli Multidisciplinary biology Pseudomonas aeruginosa Chemistry Antimicrobial biology.organism_classification 030104 developmental biology Staphylococcus aureus lcsh:H1-99 030217 neurology & neurosurgery Biotechnology lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 5, Iss 10, Pp e02592-(2019) |
| ISSN: | 2405-8440 |
| Popis: | A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product. |
| Databáze: | OpenAIRE |
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