Effect of cacao polyphenol-rich chocolate on postprandial glycemia, insulin, and incretin secretion in healthy participants
| Autor: | Natsuki Yagi, Yuki Watanabe, Hidekazu Arai, Tatsuya Morimoto, Midori Natsume, Kiyonori Kuriki, Ayako Sawazaki, Yuka Kawakami, Megumi Koganei, Megumi Mazuka, Toshihiko Asai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Incretin 030209 endocrinology & metabolism Gastric Inhibitory Polypeptide Dark chocolate Glucagon Incretins 03 medical and health sciences 0302 clinical medicine food Internal medicine medicine Humans Insulin Chocolate Glycemic Cacao 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies business.industry food and beverages Polyphenols Postprandial Period Crossover study Glucagon-like peptide-1 food.food Healthy Volunteers Postprandial Endocrinology business |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 85 |
| ISSN: | 1873-1244 |
| Popis: | There is substantial interest in using dark chocolate to prevent postprandial hyperglycemia. We investigated the effects of cacao polyphenol-rich chocolate on postprandial glycemic and insulinemic responses and whether cacao polyphenol-rich chocolate increases glucagon-like peptide-1 (GLP-1) secretion.In a stratified, randomized, crossover study, 48 healthy participants ingested either water (W) or cacao polyphenol-rich chocolate plus water (C) 15 min before a 50 g oral glucose tolerance test (OGTT). Pre- and postprandial concentrations of blood glucose, insulin, free fatty acid, glucagon, and GLP-1 were evaluated.Peak plasma glucose concentrations did not differ significantly between groups W and C; however, plasma glucose concentrations at 120 min in group C were significantly lower than those in group W (P.01). Postprandial serum insulin and plasma GLP-1 concentrations and incremental serum insulin and plasma GLP-1 area under the curve (AUC)This study indicated that the intake of cacao polyphenol-rich chocolate before a 50 g OGTT could enhance early insulin and GLP-1 secretion in healthy participants, and illustrates the potential of cacao polyphenol-rich chocolate in managing postprandial glucose excursions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect