Specific thermographic changes during Walker 256 carcinoma development: differential infrared imaging of tumour, inflammation and haematoma
| Autor: | Neven Zarkovic, Kamelija Zarkovic, Morana Jaganjac, Darko Kolarić, Karolj Skala, Marija Poljak-Blazi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Infrared Rays infrared thermal imaging Walker 256 carcinoma haematoma inflammation Inflammation Neovascularization Rats Sprague-Dawley Hematoma medicine Carcinoma Animals Carcinoma 256 Walker Skin Neovascularization Pathologic business.industry Cancer medicine.disease Peripheral Rats Transplantation Oncology Regional Blood Flow Thermography medicine.symptom business Skin Temperature |
| Zdroj: | Cancer detection and prevention. 32(5-6) |
| ISSN: | 1525-1500 |
| Popis: | Background : Infrared imaging measures spatial variations in the skin temperature aiming to determine pathological processes; hence possible use of this non-invasive analytical method in cancer detection is emerging. Methods : Infrared thermal imaging was used to detect changes in rat skin surface temperature associated with experimental cancer development (Walker 256 carcinoma), inflammation (upon s.c. Sephadex injection) and haematoma (provoked by s.c. blood coagulate injection). Infrared camera with a geometric resolution of 76,800 pixels, spectral range of 8–14μm and the minimal detectable temperature resolution of 0.07°C with spatial resolution of 0.48mm at measuring distance of 30cm was used to obtain computerised thermal scans. Genuine ThermoWEB software developed for remote internet control as open source software was used. Results : The raise of peripheral temperature was observed after induction of local inflammation or haematoma. Opposite to that, transient decrease of the skin surface temperature was observed after tumour transplantation. Progressive growth of tumour was associated with the raise of the skin surface temperature from the 10th day after tumour inoculation, when the tumours developed supportive neoangiogenic blood supply, as verified by histology. Conclusion : While the raise of peripheral temperature in advanced tumour was caused by neoangiogenesis, the reduction in skin surface temperature in an early period after tumour cell inoculation indicated a decay of transplanted tumour cells due to the immune response and the lack of blood supply. Thus, infrared thermal imaging may have considerable value in evaluation of the tumour development and discrimination of cancer from inflammation and haematoma. |
| Databáze: | OpenAIRE |
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