In vivo labeling of platelets with 75Se -- selenomethionine in patients with hepatic cirrhosis and thrombocytopenia
| Autor: | Ilse Herrmann, U. Kempgens, Wolfgang Queisser, M. Mayer |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Blood Platelets Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Time Factors Platelet maturation chemistry.chemical_element Megakaryocyte In vivo Internal medicine medicine Methods Humans Platelet Vitamin B12 Selenomethionine business.industry Hematology Middle Aged medicine.disease Thrombocytopenia medicine.anatomical_structure Endocrinology chemistry Female Bone marrow business Megakaryocytes Selenium |
| Zdroj: | Thrombosis and haemostasis. 37(1) |
| ISSN: | 0340-6245 |
| Popis: | SummaryLabeling of platelets in vivo by 75Se – Selenomethionine (75Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation of the kinetics of platelet maturation. Folic acid and vitamin B12 deficiency was excluded by pretreatment of the patients with these agents. The platelet maturation time – time between the injection of the isotope and maximum radioactivity of separated blood platelets – was shortened to 7.7±1.1 days (mean±SD) compared to the normal of 9.1±1.4 days. For explanation a disturbance of megakaryocyte maturation and/or platelet release from the bone marrow is suggested. |
| Databáze: | OpenAIRE |
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